To change the location of TempSave folder button to change the paths to local drive locations. To change the location of UFF, Autosave, Unsaved and Backup folder In this case, please try to move all folders(UFF, Autosave, Unsaved, TempSave, and Backup folder) from network to the local drive.
Even if you have changed the location of User Files Folder to be a local path, the file's read-only warning might still pops up when saving it. When this happens, you might check whether you have the User Files Folder(UFF), Autosave, Unsaved, TempSave, and Backup folder on a network drive. Sometimes, when you are saving an Origin project file(*.opju) in Origin 2018b or later, Origin might declares that the saving file is read-only. 5.66 FAQ-932 Why does Origin declare the saving file is read-only?